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Clinical Trials

Clinical Trial Image of a keyboard, pen, stethoscope and heart over a pink background

Patient involvement in clinical trials is crucial to our community. The first ever clinical trial for MOGAD was announced in October of 2021!  As research moving forward, there will be more clinical trials in the near future.

Please Keep checking all trial links as sites are continually being identified

What is a Clinical Trial and how does it work?

Our contacts at Roche/Genentech have generously supplied a great video for you to watch to help you understand what you need to know about clinical trials in general.  Watch the video below for a great overview:

Current Clinical Trials for MOGAD

CosMOG

Sponsored by UCB Biopharma SRL

A Study to Evaluate the Efficacy and Safety of Rozanolixizumab in Adult Participants With Myelin Oligodendrocyte Glycoprotein (MOG) Antibody-associated Disease (MOG-AD) (cosMOG)

Learn more about the study from the CosMOG website.

There is also more information and someone to connect to to answer questions and help connect you to specialists at KnowRare.

Watch these videos to help you understand the cosMOG Trial

These two videos provide a great review of what Rozanolixizumab does as well as a friendly discussion with Dr. Michael Levy and two MOGAD patients who are currently in the clinical trial.

Meteoroid

Sponsored by Hoffmann-La Roche

A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Satralizumab in Patients With Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (Meteoroid)

Learn more about the study from the Meteoroid website. (source https://forpatients.roche.com/).

The infographics below will help you understand the process in this trial courtesy of https://forpatients.roche.com/:

The MOG Project Logo. What does the meteroid (WN43194) Clinical Trial Look Like? Source https://forpatients.roche.com/.
The MOG Project Logo. Can I take Part in the Clinical Trial? If the Trial is open to new patients, you doctor will run tests to see if the clinical trial is open to you. If you have been diagnosed with MOGAD according to certain criteria and the clinical trial is suitable for You, your doctor will explain the clinical trial and the rights that you have so YOU can decide if you want to take part. If you want to take part, you will be entered into one of two different treatment groups randomly (Like flipping a coin). Source https://forpatients.roche.com/.
The MOG Project Logo. What Treatment Will I be Given? Part 1: Double Blind Period: First Group: Depending on your weight, you will be given one or two injections of satralizumab under the skin (subcutaneous) every four weeks, plus an extra dose at Week 2. You may continue to receive your regular (Background) Therapy prescribed to prevent MOGAD relapses. Second Group: Depending on your weight, you will be given one or two injections of placebo under the skin (subcutaneous) every four weeks, plus an extra dose at Week 2. You may continue to receive your regular (background) therapy prescribed to prevent MOGAD relapses. All Groups: You will be given satralizumab or placebo until researchers have seen a certain number of MOGAD attacks (relapses) among clinical trial participants. Part 2: open Label Period: If you decide to enter Part 2 of the clinical trial, you will be given satralizumab, with or without background therapy, for up to two years even if You received placebo in Part 1. Both you and your clinical trial doctor will know you are receiving satralizumaB treatment during this part of the clinical trial. (Source https://forpatients.roche.com/)
The MOG Project Logo. What Happens During the Clinical Trial? During the clinical trial, your scheduled clinic visits will include checks to see how you are responding to the treatment and if you are experiencing any side effects. Clinical trial doctors will perform these checks. These will happen before you are given your next dose of clinical trIal treatment. After your final dose, you will still have regular check-ups with your clinical trial doctor every four weeks. These check-ups will be done over the phone to check for any side effects that you might be having. All participants will have a clinic visit for final tests after 12 weeks, and again after another 12 weeks if you are an adolescent. You can leave this clinical trial at any time, and you will not lose access to your regular care. (Source https://forpatients.roche.com/)
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Tolerization

While not yet a clinical trial, one of the most exciting areas of research is Tolerization for the MOG antibody.  It is also being looked at for the AQP-4 antibody as well, which is detectable in many NMOSD patients.

The Guthy-Jackson Charitable Foundation has this page on the subject.  We share this with you so that you can watch as this area of research develops:

 

Pioneer | Curative Therapies

 

It is hoped that this will trnaslate to clinical trials in the near future.