The MOG Initiative
The Neuroimmunology Clinic and Research Laboratory
Massachusetts General Hospital
Dr. Levy and the staff at The Neuroimmunology Clinic and Research Laboratory are pleased to share their research plans to help understand, diagnose, treat, and hopefully, one day, cure MOG Antibody DiseaseOften referred to as MOGAD, Anti-MOG, MOG Ab+, MOG Antibody Disease, MOG Associated Antibody Disease, MOG positive disease (MOGADOften referred to as MOGAD, Anti-MOG, MOG Ab+, MOG Antibody Disease, MOG Associated Antibody Disease, MOG positive disease ):
- Creation of an online survey of MOGA type of protein involved in cell adhesion. Present throughout myelin sheaths. patients to determine efficacy of therapies
In partnership with The MOGA type of protein involved in cell adhesion. Present throughout myelin sheaths. Project, they are reaching out to MOG patients in order to create a database of information that will help determine the best treatments for MOGADOften referred to as MOGAD, Anti-MOG, MOG Ab+, MOG Antibody Disease, MOG Associated Antibody Disease, MOG positive disease . They will publish the results of this survey to help patients and their physicians make informed decisions. They may also use the information garnered to develop clinical trials in MOG antibody diseaseOften referred to as MOGAD, Anti-MOG, MOG Ab+, MOG Antibody Disease, MOG Associated Antibody Disease, MOG positive disease .
- Mouse models to investigate tolerization
They have been using mouse models to help develop therapies that will re-educate the immune system to stop attacking the myelin oligodendrocyte glycoprotein (MOG)A type of protein involved in cell adhesion. Present throughout myelin sheaths..
They are currently working with two companies to create pathways of potential tolerization in MOGA type of protein involved in cell adhesion. Present throughout myelin sheaths. mice with the goal to move these approaches to trials in humans.
- Exploration of repurposing existing medications to stop MOGA type of protein involved in cell adhesion. Present throughout myelin sheaths. disease activity
They are looking into the possibility that existing medications might be used to treat MOGADOften referred to as MOGAD, Anti-MOG, MOG Ab+, MOG Antibody Disease, MOG Associated Antibody Disease, MOG positive disease .
In partnership with The MOGA type of protein involved in cell adhesion. Present throughout myelin sheaths. Project and researchers from the University of Missouri, they will take blood samples from patients and examine the levels of natural oxysterols (cholesterol compounds). The goal is to understand the role of cholesterol products in MOG antibody diseaseOften referred to as MOGAD, Anti-MOG, MOG Ab+, MOG Antibody Disease, MOG Associated Antibody Disease, MOG positive disease and to find new ways to stop MOGA type of protein involved in cell adhesion. Present throughout myelin sheaths. disease activity.
- Upcoming clinical trials for MOGADOften referred to as MOGAD, Anti-MOG, MOG Ab+, MOG Antibody Disease, MOG Associated Antibody Disease, MOG positive disease patients.
Dr, Levy recenly announced the FIRST EVER Clinical TrialResearch studies performed using people as subjects that are aimed at evaluating a medical, surgical, or behavioral intervention to determine to what degree a new treatment (e.g., drugs or medical devices) is safe and effective for general populations. for MOG-ADOften referred to as MOGAD, Anti-MOG, MOG Ab+, MOG Antibody Disease, MOG Associated Antibody Disease, MOG positive disease as shown in the video below. Two more are expected in the coming months. When these trials launch, they will reach out to you, the patient community, to determine if you want to participate in a trial.
Let's hear the latest from Dr. Levy about what's happening at the MOG Initiative
As they pursue these avenues of research, your help is needed to make it happen
Here are some ways to participate:
- Please support The MOG Initiative to help further MOG-AD research at the Neuroimmunology Clinic and Research Laboratory at Massachusetts General Hospital
- Please support the Neuroimmunology Clinic and Research Laboratory in providing outstanding personal care, raising awareness, and finding improved treatments and ultimately, a cure.
- Are you (or have you been) a patient at Massachusetts General hospital? If so, please donate blood to our biobank by contacting Gabriela Romanow at gromanow@mgh.harvard.edu
- If you have MOG and are related to anyone else with MOG, please contact Gabriela at gromanow@mgh.harvard.edu.