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MOGCast Follow-Up

MOG-AD Diagnosis: Testing and Titers

In June of 2021, The MOGA type of protein involved in cell adhesion. Present throughout myelin sheaths. Project was joined by Dr. John Chen and Dr. Eoin Flanagan from the Mayo Clinic in our first of the MOGCast Series called MOG-ADOften referred to as MOGAD, Anti-MOG, MOG Ab+, MOG Antibody Disease, MOG Associated Antibody Disease, MOG positive disease   Diagnosis: Testing and Titers. Dr. Chen and Dr. Flanagan have answered 8 important community questions that we did not have time to ask during the MOGCast. OnInflammation of the optic nerve that may be classified as unilateral (affecting one eye) or bilateral (affecting both eyes) that may result in vision changes, vision loss, and/or pain with eye movement. behalf of The MOGA type of protein involved in cell adhesion. Present throughout myelin sheaths. Project and the MOG-ADOften referred to as MOGAD, Anti-MOG, MOG Ab+, MOG Antibody Disease, MOG Associated Antibody Disease, MOG positive disease   Community, we would like to thank Dr. Chen and Dr. Flanagan for taking the time to help the community understand the diagnosis of MOG-ADOften referred to as MOGAD, Anti-MOG, MOG Ab+, MOG Antibody Disease, MOG Associated Antibody Disease, MOG positive disease  , how to test and treat the disease, what the titers indicate, and all the research they continue to undertake onInflammation of the optic nerve that may be classified as unilateral (affecting one eye) or bilateral (affecting both eyes) that may result in vision changes, vision loss, and/or pain with eye movement. MOGA type of protein involved in cell adhesion. Present throughout myelin sheaths. Antibody-Associated Disorder. You can view to the entire MOGCast here. Blog Questions Is there any hope of new treatment in the future? Our understanding of MOG-ADOften referred to as MOGAD, Anti-MOG, MOG Ab+, MOG Antibody Disease, MOG Associated Antibody Disease, MOG positive disease   is growing. Many of our prior treatments were extensions of what we have done for NMOSDA disorder of the central nervous system that primarily affects the nerves of the eye and the spinal cord. Also known as Neuromyelitis Optica (NMO) or Devic’s Disease, but MOG-ADOften referred to as MOGAD, Anti-MOG, MOG Ab+, MOG Antibody Disease, MOG Associated Antibody Disease, MOG positive disease   is a different disease. maintenance IVIGA human blood donor product made up of immunoglobulins (IgG and IgM antibodies) derived from plasma that can be administered intravenously (IVIG) or subcutaneously (SCIG). For myelin oligodendrocyte glycoprotein antibody disease (MOGAD), it is used as an immunomodulator to reduce disease activity. Sometimes used for acute attacks or as an ongoing preventative treatment. may be an effective treatment for MOG-ADOften referred to as MOGAD, Anti-MOG, MOG Ab+, MOG Antibody Disease, MOG Associated Antibody Disease, MOG positive disease  . There are likely to be randomized clinical trials for new treatments coming soon. If someone has MOGA type of protein involved in cell adhesion. Present throughout myelin sheaths. Optic NeuritisInflammation of the optic nerve that may be classified as unilateral (affecting one eye) or bilateral (affecting both eyes) that may result in vision changes, vision loss, and/or pain with eye movement. and they are high myopic, how does that affect the interpretation of the OCTA noninvasive imaging technology used to obtain high resolution cross-sectional images of the retina. The layers within the retina can be differentiated and retinal thickness can be measured to aid in the early detection and diagnosis of retinal diseases and conditions such as damage causd by optic neuritis in MOGAD. and Visual Field Test? High refractive error, such as high myopia, will not influence visual field tests, but can alter the interpretation of the OCTs. OCTs are color coded as green (normal), yellow (mildly thin), and red (thin) when comparing a patient’s RNFL or GC-IPL thickness against the age-matched control database. However, the database of age-matched controls are from patients without much refractive error. Therefore, if a patient is highly myopic, the numbers do not match up with the age-matched controls (high myopia tends to have thinner RNFL). For this reason, it is helpful to have a baseline OCTA noninvasive imaging technology used to obtain high resolution cross-sectional images of the retina. The layers within the retina can be differentiated and retinal thickness can be measured to aid in the early detection and diagnosis of retinal diseases and conditions such as damage causd by optic neuritis in MOGAD. for an individual patient so changes can be followed over time rather than depending onInflammation of the optic nerve that may be classified as unilateral (affecting one eye) or bilateral (affecting both eyes) that may result in vision changes, vision loss, and/or pain with eye movement. a comparison of the thickness against the age-matched controls. If you were reaching out to the public for awareness purposes, what age group would you target? We would need to reach out to all ages because MOG-ADOften referred to as MOGAD, Anti-MOG, MOG Ab+, MOG Antibody Disease, MOG Associated Antibody Disease, MOG positive disease   can affect any age. Children and parents of children would also be very important because MOG-ADOften referred to as MOGAD, Anti-MOG, MOG Ab+, MOG Antibody Disease, MOG Associated Antibody Disease, MOG positive disease   likely accounts for about a quarter of demyelinatingThe process in which the protective coating of nerve tissue (i.e. myelin) becomes damaged or breaks down, causing nerve impulses to slow or halt that results in neurological problems. disease in children. After stopping preventiveRefers to a medication or treatment that is administered to prevent future relapses (Also referred to as Preventative or Preventive Treatment). medications and negative for the MOGA type of protein involved in cell adhesion. Present throughout myelin sheaths. antibodyA protective protein produced by your immune system that attaches to antigens (foreign substances), such as bacteria and toxins, and removes them from your body. In myelin oligodendrocyte glycoproten antibody disease (MOGAD), the body incorrectly produces an antibody that targets myelin oligodendrocyte glycoprotein, a component of the myelin sheath in the central nervous system., how often should patients be retested in the remission phase?

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Dr. Michael Levy’s Statement on the COVID-19 Vaccines and MOG-AD

Many in our MOG-ADOften referred to as MOGAD, Anti-MOG, MOG Ab+, MOG Antibody Disease, MOG Associated Antibody Disease, MOG positive disease   community have been asking whether they should consider taking the COVID-19 vaccination.  Michael Levy, MD, PhD and Head of The NMO Clinic and Research Laboratory at Massachusetts General Hospital, recently made a supporting statement on the The NMO Clinic private Facebook group. We wanted to share this to our email subscribers and members of our private Facebook group, MOG Antibody / Anti MOG Support And Info. Vaccination is a big decision and unique to each individual, which makes it a personal journey with their treating medical professional. The intent of this post is to help guide the personal decision-making process with factual information and insight.  The following statement, while written in the context of NMOSDA disorder of the central nervous system that primarily affects the nerves of the eye and the spinal cord. Also known as Neuromyelitis Optica (NMO) or Devic’s Disease, provides direction from Dr. Levy, which he has confirmed is also applicable to MOG-ADOften referred to as MOGAD, Anti-MOG, MOG Ab+, MOG Antibody Disease, MOG Associated Antibody Disease, MOG positive disease  .  His statement is as follows, reprinted with his permission: NOTE: Since this initial post, Dr. Michael Levy has updated his statement with additional considerations: “Very important point.  If a vaccine triggered a relapseWhen you present to your doctor or hospital with new or worsening central nervous system symptoms. Generally, if your symptoms gradually worsen over 24-48 hours, there is heightened concern of a relapse. (Also referred to as a flare by the myelin oligodendrocyte glycoproten antibody disease (MOGAD) community). in the past, you should NOT get the COVID vaccine, just in case. Based onInflammation of the optic nerve that may be classified as unilateral (affecting one eye) or bilateral (affecting both eyes) that may result in vision changes, vision loss, and/or pain with eye movement. the data I’ve reviewed in the Pfizer filing, it appears that the RNA COVID vaccine they released should be relatively safe for NMO patients. As with any vaccine, it is safer to get the vaccine while onInflammation of the optic nerve that may be classified as unilateral (affecting one eye) or bilateral (affecting both eyes) that may result in vision changes, vision loss, and/or pain with eye movement. NMO therapy even if the efficacy is dulled a little.  Both the Pfizer and Moderna vaccines add a second booster shot so I don’t think any of the immunotherapies will interfere with efficacy. I don’t know the risk of relapseWhen you present to your doctor or hospital with new or worsening central nervous system symptoms. Generally, if your symptoms gradually worsen over 24-48 hours, there is heightened concern of a relapse. (Also referred to as a flare by the myelin oligodendrocyte glycoproten antibody disease (MOGAD) community). from the vaccine.  It does not include any adjuvants so I do not think it is likely to trigger a relapseWhen you present to your doctor or hospital with new or worsening central nervous system symptoms. Generally, if your symptoms gradually worsen over 24-48 hours, there is heightened concern of a relapse. (Also referred to as a flare by the myelin oligodendrocyte glycoproten antibody disease (MOGAD) community).. There are side effects, especially after the second shot, including pain, soreness and swelling at the site of the injection, as well as headaches and fatigue in more than half of participants.  The placebo group also got lots of headaches and fatigue, but the vaccine group got more.  Out of 30,000+ participants, there were < 0.1% rare serious events which were largely divided equally between the vaccine and placebo arms.  Those serious events were things like appendicitis that NMO patients are not at risk for.  So overall, I would recommend NMO patients take the RNA vaccine if they have the opportunity to do so.” Dr. Levy is an Associate Professor in Neurology who was recently recruited to lead the research unit in the new Division of Neuroimmunology at the Massachusetts General Hospital. His mission is to build a combined clinical and research neuroimmunology program to develop therapies for patients with autoimmuneA disease in which the immune system incorrectly targets and attacks an individual’s own healthy cells. diseases of the central nervous systemNerve tissue that resides in and composes the brain, spinal cord, and optic nerve. Dr. Levy moved from Baltimore, MD, where he was onInflammation of the optic nerve that may be classified as unilateral (affecting one eye) or bilateral (affecting both eyes) that may result in vision changes, vision loss, and/or pain with eye movement. the faculty at Johns Hopkins University since 2009 and Director of the Neuromyelitis Optica Clinic. You can read more about Dr. Levy onInflammation of the optic nerve that may be classified as unilateral (affecting one eye) or bilateral (affecting both eyes) that may result in vision changes, vision loss, and/or pain with eye movement. our website:  https://mogproject.org/about/#levy   You can also read about his MOGA type of protein involved in cell adhesion. Present throughout myelin sheaths. Initiative at Massachusetts General Hospital onInflammation of the optic nerve that may be classified as unilateral (affecting one eye) or bilateral (affecting both eyes) that may result in vision changes, vision loss, and/or pain with eye movement. our website: https://mogproject.org/resources/from-our-medical-advisory-board/the-mog-initiative/

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