
MOG-AD Diagnosis: Testing and Titers
In June of 2021, The MOGA type of protein involved in cell adhesion. Present throughout myelinAn insulating layer, or sheath that forms around nerves, including those in the brain and spinal cord. It is made up of protein and fatty substances. This myelin sheath allows electrical impulses to transmit quickly and efficiently along the nerve cells. If myelin is damaged, these impulses slow down. sheaths. Project was joined by Dr. John Chen and Dr. Eoin Flanagan from the Mayo Clinic in our first of the MOGCast Series called MOG-ADOften referred to as MOGADOften referred to as MOGAD, Anti-MOG, MOG Ab+, MOG Antibody Disease, MOG Associated Antibody Disease, MOG positive disease , Anti-MOG, MOGA type of protein involved in cell adhesion. Present throughout myelin sheaths. Ab+, MOG Antibody DiseaseOften referred to as MOGAD, Anti-MOG, MOG Ab+, MOG Antibody Disease, MOG Associated Antibody Disease, MOG positive disease , MOGA type of protein involved in cell adhesion. Present throughout myelin sheaths. Associated AntibodyA protective protein produced by your immune system that attaches to antigens (foreign substances), such as bacteria and toxins, and removes them from your body. In myelin oligodendrocyte glycoproten antibody disease (MOGAD), the body incorrectly produces an antibody that targets myelin oligodendrocyte glycoprotein, a component of the myelin sheath in the central nervous system. Disease, MOGA type of protein involved in cell adhesion. Present throughout myelin sheaths. positive disease Diagnosis: Testing and Titers. Dr. Chen and Dr. Flanagan have answered 8 important community questions that we did not have time to ask during the MOGCast. OnInflammation of the optic nerveThe cranial nerves that relay messages from your eyes to your brain to create visual images. These nerves extend from the retina in the back of the eyes to the part of the brain that processes what we see. In myelin oligodendrocyte glycoproten antibody disease (MOGAD), they may be the target of inflammation or lesions, sometimes causing visual disruption or blindness. that may be classified as unilateralRefers to disease or attack on a single side. (affecting one eye) or bilateralRefers to disease or attack on two sides. (affecting both eyes) that may result in vision changes, vision loss, and/or pain with eye movement. behalf of The MOGA type of protein involved in cell adhesion. Present throughout myelinAn insulating layer, or sheath that forms around nerves, including those in the brain and spinal cord. It is made up of protein and fatty substances. This myelin sheath allows electrical impulses to transmit quickly and efficiently along the nerve cells. If myelin is damaged, these impulses slow down. sheaths. Project and the MOG-ADOften referred to as MOGADOften referred to as MOGAD, Anti-MOG, MOG Ab+, MOG Antibody Disease, MOG Associated Antibody Disease, MOG positive disease , Anti-MOG, MOGA type of protein involved in cell adhesion. Present throughout myelin sheaths. Ab+, MOG Antibody DiseaseOften referred to as MOGAD, Anti-MOG, MOG Ab+, MOG Antibody Disease, MOG Associated Antibody Disease, MOG positive disease , MOGA type of protein involved in cell adhesion. Present throughout myelin sheaths. Associated AntibodyA protective protein produced by your immune system that attaches to antigens (foreign substances), such as bacteria and toxins, and removes them from your body. In myelin oligodendrocyte glycoproten antibody disease (MOGAD), the body incorrectly produces an antibody that targets myelin oligodendrocyte glycoprotein, a component of the myelin sheath in the central nervous system. Disease, MOGA type of protein involved in cell adhesion. Present throughout myelin sheaths. positive disease Community, we would like to thank Dr. Chen and Dr. Flanagan for taking the time to help the community understand the diagnosis of MOG-ADOften referred to as MOGADOften referred to as MOGAD, Anti-MOG, MOG Ab+, MOG Antibody Disease, MOG Associated Antibody Disease, MOG positive disease , Anti-MOG, MOGA type of protein involved in cell adhesion. Present throughout myelin sheaths. Ab+, MOG Antibody DiseaseOften referred to as MOGAD, Anti-MOG, MOG Ab+, MOG Antibody Disease, MOG Associated Antibody Disease, MOG positive disease , MOGA type of protein involved in cell adhesion. Present throughout myelin sheaths. Associated AntibodyA protective protein produced by your immune system that attaches to antigens (foreign substances), such as bacteria and toxins, and removes them from your body. In myelin oligodendrocyte glycoproten antibody disease (MOGAD), the body incorrectly produces an antibody that targets myelin oligodendrocyte glycoprotein, a component of the myelin sheath in the central nervous system. Disease, MOGA type of protein involved in cell adhesion. Present throughout myelin sheaths. positive disease , how to test and treat the disease, what the titers indicate, and all the research they continue to undertake onInflammation of the optic nerveThe cranial nerves that relay messages from your eyes to your brain to create visual images. These nerves extend from the retina in the back of the eyes to the part of the brain that processes what we see. In myelin oligodendrocyte glycoproten antibody disease (MOGAD), they may be the target of inflammation or lesions, sometimes causing visual disruption or blindness. that may be classified as unilateralRefers to disease or attack on a single side. (affecting one eye) or bilateralRefers to disease or attack on two sides. (affecting both eyes) that may result in vision changes, vision loss, and/or pain with eye movement. MOGA type of protein involved in cell adhesion. Present throughout myelinAn insulating layer, or sheath that forms around nerves, including those in the brain and spinal cord. It is made up of protein and fatty substances. This myelin sheath allows electrical impulses to transmit quickly and efficiently along the nerve cells. If myelin is damaged, these impulses slow down. sheaths. Antibody-Associated Disorder. You can view to the entire MOGCast here. Blog Questions Is there any hope of new treatment in the future? Our understanding of MOG-ADOften referred to as MOGADOften referred to as MOGAD, Anti-MOG, MOG Ab+, MOG Antibody Disease, MOG Associated Antibody Disease, MOG positive disease , Anti-MOG, MOGA type of protein involved in cell adhesion. Present throughout myelin sheaths. Ab+, MOG Antibody DiseaseOften referred to as MOGAD, Anti-MOG, MOG Ab+, MOG Antibody Disease, MOG Associated Antibody Disease, MOG positive disease , MOGA type of protein involved in cell adhesion. Present throughout myelin sheaths. Associated AntibodyA protective protein produced by your immune system that attaches to antigens (foreign substances), such as bacteria and toxins, and removes them from your body. In myelin oligodendrocyte glycoproten antibody disease (MOGAD), the body incorrectly produces an antibody that targets myelin oligodendrocyte glycoprotein, a component of the myelin sheath in the central nervous system. Disease, MOG positive disease is growing. Many of our prior treatments were extensions of what we have done for NMOSDA disorder of the central nervous systemNerve tissue that resides in and composes the brain, spinal cord, and optic nerve that primarily affects the nerves of the eye and the spinal cord. Also known as Neuromyelitis Optica (NMO) or Devic’s Disease, but MOG-ADOften referred to as MOGADOften referred to as MOGAD, Anti-MOG, MOG Ab+, MOG Antibody Disease, MOG Associated Antibody Disease, MOG positive disease , Anti-MOG, MOGA type of protein involved in cell adhesion. Present throughout myelin sheaths. Ab+, MOG Antibody DiseaseOften referred to as MOGAD, Anti-MOG, MOG Ab+, MOG Antibody Disease, MOG Associated Antibody Disease, MOG positive disease , MOGA type of protein involved in cell adhesion. Present throughout myelin sheaths. Associated AntibodyA protective protein produced by your immune system that attaches to antigens (foreign substances), such as bacteria and toxins, and removes them from your body. In myelin oligodendrocyte glycoproten antibody disease (MOGAD), the body incorrectly produces an antibody that targets myelin oligodendrocyte glycoprotein, a component of the myelin sheath in the central nervous system. Disease, MOGA type of protein involved in cell adhesion. Present throughout myelin sheaths. positive disease is a different disease. maintenance IVIGA human blood donor product made up of immunoglobulins (IgG and IgM antibodiesA protective protein produced by your immune system that attaches to antigens (foreign substances), such as bacteria and toxins, and removes them from your body. In myelin oligodendrocyte glycoproten antibody disease (MOGAD), the body incorrectly produces an antibody that targets myelin oligodendrocyte glycoprotein, a component of the myelin sheath in the central nervous system.) derived from plasma that can be administered intravenouslyA way of giving a drug or other substance through a needle or tube inserted into a vein. (IVIGA human blood donor product made up of immunoglobulins (IgG and IgM antibodies) derived from plasma that can be administered intravenously (IVIG) or subcutaneously (SCIG). For myelin oligodendrocyte glycoprotein antibody disease (MOGAD), it is used as an immunomodulator to reduce disease activity. Sometimes used for acute attacks or as an ongoing preventative treatment.) or subcutaneously (SCIGA human blood donor product made up of immunoglobulins (IgG and IgM antibodies) derived from plasma that can be administered intravenously (IVIG) or subcutaneously (SCIG). For myelin oligodendrocyte glycoprotein antibody disease (MOGAD), it is used as an immunomodulator to reduce disease activity. Sometimes used for acute attacks or as an ongoing preventative treatment.). For myelin oligodendrocyte glycoprotein antibody disease (MOGAD)Often referred to as MOGAD, Anti-MOG, MOG Ab+, MOG Antibody Disease, MOG Associated Antibody Disease, MOG positive disease , it is used as an immunomodulatorA substance that affects the function of the immune system, either stimulating or suppressing its activity to reduce disease activity. Sometimes used for acuteThe severe and sudden onset of a disease process. attacks or as an ongoing preventativeRefers to a medication or treatment that is administered to prevent future relapses (Also referred to as Preventative or Preventive Treatment). treatment. may be an effective treatment for MOG-ADOften referred to as MOGADOften referred to as MOGAD, Anti-MOG, MOG Ab+, MOG Antibody Disease, MOG Associated Antibody Disease, MOG positive disease , Anti-MOG, MOGA type of protein involved in cell adhesion. Present throughout myelin sheaths. Ab+, MOG Antibody DiseaseOften referred to as MOGAD, Anti-MOG, MOG Ab+, MOG Antibody Disease, MOG Associated Antibody Disease, MOG positive disease , MOGA type of protein involved in cell adhesion. Present throughout myelin sheaths. Associated AntibodyA protective protein produced by your immune system that attaches to antigens (foreign substances), such as bacteria and toxins, and removes them from your body. In myelin oligodendrocyte glycoproten antibody disease (MOGAD), the body incorrectly produces an antibody that targets myelin oligodendrocyte glycoprotein, a component of the myelin sheath in the central nervous system. Disease, MOGA type of protein involved in cell adhesion. Present throughout myelin sheaths. positive disease . There are likely to be randomized clinical trials for new treatments coming soon. If someone has MOGA type of protein involved in cell adhesion. Present throughout myelinAn insulating layer, or sheath that forms around nerves, including those in the brain and spinal cord. It is made up of protein and fatty substances. This myelin sheath allows electrical impulses to transmit quickly and efficiently along the nerve cells. If myelin is damaged, these impulses slow down. sheaths. Optic NeuritisInflammation of the optic nerveThe cranial nerves that relay messages from your eyes to your brain to create visual images. These nerves extend from the retina in the back of the eyes to the part of the brain that processes what we see. In myelin oligodendrocyte glycoproten antibody disease (MOGAD), they may be the target of inflammation or lesions, sometimes causing visual disruption or blindness. that may be classified as unilateralRefers to disease or attack on a single side. (affecting one eye) or bilateralRefers to disease or attack on two sides. (affecting both eyes) that may result in vision changes, vision loss, and/or pain with eye movement. and they are high myopic, how does that affect the interpretation of the OCTA noninvasive imaging technology used to obtain high resolution cross-sectional images of the retina. The layers within the retina can be differentiated and retinal thickness can be measured to aid in the early detection and diagnosis of retinal diseases and conditions such as damage causd by optic neuritisInflammation of the optic nerve that may be classified as unilateral (affecting one eye) or bilateral (affecting both eyes) that may result in vision changes, vision loss, and/or pain with eye movement. in MOGAD. and Visual Field Test? High refractive error, such as high myopia, will not influence visual field tests, but can alter the interpretation of the OCTs. OCTs are color coded as green (normal), yellow (mildly thin), and red (thin) when comparing a patient’s RNFL or GC-IPL thickness against the age-matched control database. However, the database of age-matched controls are from patients without much refractive error. Therefore, if a patient is highly myopic, the numbers do not match up with the age-matched controls (high myopia tends to have thinner RNFL). For this reason, it is helpful to have a baseline OCTA noninvasive imaging technology used to obtain high resolution cross-sectional images of the retina. The layers within the retina can be differentiated and retinal thickness can be measured to aid in the early detection and diagnosis of retinal diseases and conditions such as damage causd by optic neuritisInflammation of the optic nerve that may be classified as unilateral (affecting one eye) or bilateral (affecting both eyes) that may result in vision changes, vision loss, and/or pain with eye movement. in MOGADOften referred to as MOGAD, Anti-MOG, MOG Ab+, MOG Antibody Disease, MOG Associated Antibody Disease, MOG positive disease . for an individual patient so changes can be followed over time rather than depending onInflammation of the optic nerveThe cranial nerves that relay messages from your eyes to your brain to create visual images. These nerves extend from the retina in the back of the eyes to the part of the brain that processes what we see. In myelin oligodendrocyte glycoproten antibody disease (MOGAD), they may be the target of inflammation or lesions, sometimes causing visual disruption or blindness. that may be classified as unilateralRefers to disease or attack on a single side. (affecting one eye) or bilateralRefers to disease or attack on two sides. (affecting both eyes) that may result in vision changes, vision loss, and/or pain with eye movement. a comparison of the thickness against the age-matched controls. If you were reaching out to the public for awareness purposes, what age group would you target? We would need to reach out to all ages because MOG-ADOften referred to as MOGADOften referred to as MOGAD, Anti-MOG, MOG Ab+, MOG Antibody Disease, MOG Associated Antibody Disease, MOG positive disease , Anti-MOG, MOGA type of protein involved in cell adhesion. Present throughout myelin sheaths. Ab+, MOG Antibody DiseaseOften referred to as MOGAD, Anti-MOG, MOG Ab+, MOG Antibody Disease, MOG Associated Antibody Disease, MOG positive disease , MOGA type of protein involved in cell adhesion. Present throughout myelin sheaths. Associated AntibodyA protective protein produced by your immune system that attaches to antigens (foreign substances), such as bacteria and toxins, and removes them from your body. In myelin oligodendrocyte glycoproten antibody disease (MOGAD), the body incorrectly produces an antibody that targets myelin oligodendrocyte glycoprotein, a component of the myelin sheath in the central nervous system. Disease, MOGA type of protein involved in cell adhesion. Present throughout myelin sheaths. positive disease can affect any age. Children and parents of children would also be very important because MOG-ADOften referred to as MOGADOften referred to as MOGAD, Anti-MOG, MOG Ab+, MOG Antibody Disease, MOG Associated Antibody Disease, MOG positive disease , Anti-MOG, MOGA type of protein involved in cell adhesion. Present throughout myelin sheaths. Ab+, MOG Antibody DiseaseOften referred to as MOGAD, Anti-MOG, MOG Ab+, MOG Antibody Disease, MOG Associated Antibody Disease, MOG positive disease , MOGA type of protein involved in cell adhesion. Present throughout myelin sheaths. Associated AntibodyA protective protein produced by your immune system that attaches to antigens (foreign substances), such as bacteria and toxins, and removes them from your body. In myelin oligodendrocyte glycoproten antibody disease (MOGAD), the body incorrectly produces an antibody that targets myelin oligodendrocyte glycoprotein, a component of the myelin sheath in the central nervous system. Disease, MOGA type of protein involved in cell adhesion. Present throughout myelin sheaths. positive disease likely accounts for about a quarter of demyelinatingThe process in which the protective coating of nerve tissue (i.e. myelinAn insulating layer, or sheath that forms around nerves, including those in the brain and spinal cord. It is made up of protein and fatty substances. This myelin sheath allows electrical impulses to transmit quickly and efficiently along the nerve cells. If myelin is damaged, these impulses slow down.) becomes damaged or breaks down, causing nerve impulses to slow or halt that results in neurological problems. disease in children. After stopping preventiveRefers to a medication or treatment that is administered to prevent future relapsesWhen you present to your doctor or hospital with new or worsening central nervous system symptoms. Generally, if your symptoms gradually worsen over 24-48 hours, there is heightened concern of a relapse. (Also referred to as a flare by the myelin oligodendrocyte glycoproten antibody disease (MOGAD) community). (Also referred to as PreventativeRefers to a medication or treatment that is administered to prevent future relapses (Also referred to as Preventative or Preventive Treatment). or PreventiveRefers to a medication or treatment that is administered to prevent future relapses (Also referred to as Preventative or Preventive Treatment). Treatment). medications and negative for the MOGA type of protein involved in cell adhesion. Present throughout myelinAn insulating layer, or sheath that forms around nerves, including those in the brain and spinal cord. It is made up of protein and fatty substances. This myelin sheath allows electrical impulses to transmit quickly and efficiently along the nerve cells. If myelin is damaged, these impulses slow down. sheaths. antibodyA protective protein produced by your immune system that attaches to antigens (foreign substances), such as bacteria and toxins, and removes them from your body. In myelinAn insulating layer, or sheath that forms around nerves, including those in the brain and spinal cord. It is made up of protein and fatty substances. This myelin sheath allows electrical impulses to transmit quickly and efficiently along the nerve cells. If myelin is damaged, these impulses slow down. oligodendrocyte glycoproten antibodyA protective protein produced by your immune system that attaches to antigens (foreign substances), such as bacteria and toxins, and removes them from your body. In myelin oligodendrocyte glycoproten antibody disease (MOGAD), the body incorrectly produces an antibody that targets myelin oligodendrocyte glycoprotein, a component of the myelin sheath in the central nervous system. disease (MOGADOften referred to as MOGAD, Anti-MOG, MOG Ab+, MOG Antibody Disease, MOG Associated Antibody Disease, MOG positive disease ), the body incorrectly produces an antibodyA protective protein produced by your immune system that attaches to antigens (foreign substances), such as bacteria and toxins, and removes them from your body. In myelin oligodendrocyte glycoproten antibody disease (MOGAD), the body incorrectly produces an antibody that targets myelin oligodendrocyte glycoprotein, a component of the myelin sheath in the central nervous system. that targets myelin oligodendrocyte glycoproteinA type of protein involved in cell adhesion. Present throughout myelin sheaths., a component of the myelinAn insulating layer, or sheath that forms around nerves, including those in the brain and spinal cord. It is made up of protein and fatty substances. This myelin sheath allows electrical impulses to transmit quickly and efficiently along the nerve cells. If myelin is damaged, these impulses slow down. sheath in the central nervous systemNerve tissue that resides in and composes the brain, spinal cord, and optic nerve., how often should patients be retested in the remission phase?

